Structure-Based Drug Discovery: A Case Study with RIPK1
Structure-based drug discovery (SBDD) is a widely used computational approach that leverages the three-dimensional structure of biological targets to identify and optimize potential drug candidates. In this introductory tutorial, we present a real-world case study using Receptor-Interacting Protein Kinase 1 (RIPK1)—a clinically relevant target involved in inflammation, neurodegeneration, and cell death pathways.